intertriginous folds - Health Topics
There was a recent phase 4 study of this drug in intertriginous areas. We found that about 83% of patients who had psoriasis in those skin folds got to clear or almost clear. How would you approach this patient who can't take the rash anymore?
Understanding the Context
Figure 1. Seborrheic dermatitis with pink scaling of paranasal skin and nasolabial folds. Roflumilast 0.3% cream (Zoryve), a phosphodiesterase-4 inhibitor, was approved in July 2022 for the treatment of plaque psoriasis, including intertriginous areas, in patients 12 years of age and ... The US Food and Drug Administration (FDA) has approved roflumilast 0.3% cream for the topical treatment of plaque psoriasis, "including intertriginous areas," in patients aged 12 years and older.
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Key Insights
High-potency corticosteroids should not be used in intertriginous areas because they can quickly cause skin atrophy, striae, and even ulceration. Weaker corticosteroids should be used on the face ... We studied roflumilast cream in intertriginous disease in the initial phase 3 studies and found that the majority of patients got to clear or almost clear. HS is a chronic inflammatory condition that commonly presents in intertriginous areas as nodules, abscesses, draining sinus tracts, and scarring.