job's syndrome - Health Topics
Knoxville News Sentinel: Job Research Foundation Awards Grant to UNC Chapel Hill Doctor to Advance Research into Job Syndrome, a Rare Disorder Since 2019, the Job Research Foundation has supported 17 scientific research projects worldwide investigating the rare disorder known as Job Syndrome. NEW YORK, NY ... Job Research Foundation Awards Grant to UNC Chapel Hill Doctor to Advance Research into Job Syndrome, a Rare Disorder Autosomal dominant hyper-IgE syndrome (AD-HIES), formerly known as Job syndrome, is a condition that affects several body systems, particularly the immune system.
Understanding the Context
Recurrent infections are common in people with this condition. Autosomal dominant Hyper-IgE Syndrome caused by STAT3 defects, called Job Syndrome, have characteristic facial, dental, and skeletal abnormalities. Patients with STAT3 HIES may have either delay of or failure in shedding of primary teeth. The characteristic facial features are usually set by age 16.
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The condition was initially called "Job syndrome," based upon a description of the biblical character Job: "so went Satan forth from the presence of the Lord and smote Job with sore boils from the sole of his foot unto his crown" (Job 2:7). Job syndrome is a rare immune deficiency disorder characterized by recurrent skin and lung infections and severe eczema. One of its main features is that individuals present extremely high serum levels of immunoglobulin E, an antibody that’s primarily associated with allergic responses. What is Job syndrome? Job syndrome, also called hyper- IgE syndrome, is the name given to a rare inherited immune deficiency characterised by severe infections of the skin and other organs.
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Autosomal dominant hyper IgE syndrome (AD-HIES), formerly known as Job syndrome, affects several body systems including the immune system. AD-HIES is characterized by abnormally high levels of an immune system protein called immunoglobulin E (IgE) in the blood. Job’s syndrome is a rare condition which affects both males and females with symptoms usually beginning in childhood. The most common features are eczema, increased susceptibility to infections and markedly raised levels of IgE (one of the classes of antibodies) on blood testing.