lichen amyloidosis - Health Topics
Lichen amyloidosis (LA) primarily affects individuals of South East Asian and Central and South American descent. The condition is less common in European or North American populations. 1,2 Although ...
Understanding the Context
Primary cutaneous amyloidosis (PCA) encompasses a group of skin conditions characterised by deposition of amyloid protein, without internal organ involvement. It is subclassified into lichen amyloidosis, macular amyloidosis, and nodular amyloidosis. A physical examination showed discrete and coalescing hyperkeratotic tan-brown papules on the pretibial surfaces (Figure 1), consistent with lichen amyloidosis. Lichen amyloidosis is the most common type of primary localized cutaneous amyloidoses (amyloid deposits are exclusively localized in the skin).
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Key Insights
The three main forms of primary localized cutaneous amyloidosis are lichen amyloidosis, macular amyloidosis, and nodular amyloidosis. Lichen amyloidosis, a cutaneous form of amyloidosis, is most commonly observed in adults and is characterized by intensely pruritic, hyperkeratotic papules that may form plaques, often in response to chronic friction or trauma. Lichen amyloidosis is a type of localized amyloidosis that affects only the skin. Because it’s thought to develop from repeated rubbing, scratching, or friction, it often appears on areas of the body that are easy to reach or rub. Lichen amyloidosis is a skin condition that can cause itching and discomfort.
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It occurs when proteins in the skin form deposits that lead to raised, itchy patches. Although the exact cause is not fully understood, factors such as genetics and chronic scratching may play a role in its development. Lichen amyloidosis accounts for approximately 10% of cases of PLCA. The pathogenesis remains undetermined, but it is considered a secondary process following chronic scratching associated with... Lichen amyloidosis (LA) is a chronic, non-contagious skin disorder that represents the most common form of Primary Localized Cutaneous Amyloidosis (PLCA). It involves the abnormal accumulation of protein deposits, known as amyloid, confined strictly to the skin.
Lichen amyloidosis is the most common variant of primary cutaneous amyloidosis (PCA) and is associated with the extracellular deposition of amyloid in the skin without associated internal organ involvement. 1 The amyloid deposits in PCA are keratinocyte-derived, primarily composed of keratinocyte 5.