Alcohol-related deaths due acute pancreatitis have risen. Learn more about acute and chronic pancreatitis from a Mayo Clinic expert. Quarterly RNA drug plozasiran turns off a liver gene, sharply lowering life‑threatening pancreatitis attacks in a rare genetic disorder.

Understanding the Context

Los Angeles Times: Beyond the Diagnosis: The Messy Reality of Managing Chronic Pancreatitis Chronic pancreatitis (CP) is an irreversible, inflammatory disease leading to fibrosis and both exocrine and endocrine pancreatic insufficiency. Pain is the most debilitating symptom of CP, and its ... The New England Journal of Medicine: Olezarsen for Managing Severe Hypertriglyceridemia and Pancreatitis Risk Patients with severe hypertriglyceridemia have an increased risk of acute pancreatitis. The efficacy and safety of olezarsen, an antisense oligonucleotide targeting apolipoprotein C-III messenger RNA, ...

Key Insights

Pancreatitis is caused by the irritation and inflammation of the cells of your pancreas. This occurs when digestive enzymes released by the pancreas become active while still in the pancreas. Researchers at Mayo Clinic have discovered how high levels of triglycerides, a type of fat found in the bloodstream, can rapidly damage organs during acute pancreatitis.