ascopubs.org: Prognostic Value of Initial Fasting Serum Gastrin Levels in Patients With Zollinger-Ellison Syndrome PURPOSE: To assess the value of the initial fasting serum gastrin (FSG) at presentation in patients with Zollinger-Ellison Syndrome (ZES) in predicting primary tumor characteristics and survival. Prognostic Value of Initial Fasting Serum Gastrin Levels in Patients With Zollinger-Ellison Syndrome Zollinger-Ellison syndrome is a condition in which one or more tumors grow in the pancreas or small intestine. The tumors, called gastrinomas, produce large amounts of the hormone gastrin.

Understanding the Context

Zollinger-Ellison syndrome (ZES) is a rare digestive disorder. If you have ZES, you likely have one or more tumors in the first part of the small intestine, the pancreas, or both. These tumors release the hormone gastrin. This causes the stomach to release too much acid and can cause painful ulcers.

Key Insights

Zollinger–Ellison syndrome (Z-E syndrome) is a disease in which tumors cause the stomach to produce too much acid, resulting in peptic ulcers. Symptoms include abdominal pain and diarrhea. Zollinger-Ellison syndrome (ZES) is a disease of the gastrointestinal system. People who have ZES develop tumors known as gastrinomas in the pancreas and duodenum (the first section of the... Learn about Zollinger-Ellison syndrome, in which tumors in the pancreas or duodenum increase stomach acid, leading to peptic ulcers, acid reflux, and diarrhea.

Final Thoughts

Zollinger-Ellison (ZES) syndrome is characterized by gastric acid hypersecretion resulting in severe acid-related peptic disease and diarrhea [1,2]. The clinical manifestations and diagnosis of ZES will be reviewed here. Zollinger-Ellison syndrome is a condition in which the body produces too much of the hormone gastrin. Most of the time, a small tumor (gastrinoma) in the pancreas or small intestine is the source of the extra gastrin in the blood. Zollinger-Ellison syndrome is caused by tumors called gastrinomas. Zollinger-Ellison syndrome is a rare condition that causes tumors called gastrinomas to grow in your pancreas and small intestine.

Gastrinomas release the hormone gastrin, which triggers your stomach to produce gastric acid. Zollinger-Ellison syndrome (ZES) is a condition caused by gastrin-producing neuroendocrine tumour that causes gastric acid hypersecretion and peptic ulcer disease. Zollinger-Ellison syndrome (ZES) is a condition in which tumors called gastrinomas in the pancreas and duodenum (part of the small intestine) cause high levels of the hormone gastrin in the blood.