acantholytic dermatosis - Health Topics
Transient acantholytic dermatosis, also known as Grover disease, is a common, acquired, itchy, truncal rash characterised by acantholysis on histopathology. Grover's disease—also called transient acantholytic dermatosis—is a rare skin condition usually causing a rash on your chest and back. The term "transient," refers to the fact that the rash comes and goes.
Understanding the Context
Grover disease, or persistent or transient acantholytic dermatosis, is a skin condition characterized by an itchy papular rash, typically on sun-damaged areas like the trunk, neck, and extremities. Transient acantholytic dermatosis, also known as Grover's disease, causes a severe rash on your chest or back. Excessive heat, sweating, and sun exposure can trigger symptoms. Symptoms of...
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Histopathologic analysis revealed a characteristic pattern of acantholysis (loss of cohesion between keratinocytes) within the epidermis, and Grover named the disease "transient acantholytic dermatosis." Once confirmed, most cases of Grover's disease last six to twelve months, which is why it was originally called "transient". However it may last much longer. Nevertheless, it is not to be confused with relapsing linear acantholytic dermatosis. Transient acantholytic dermatosis (also referred to as Grover disease) is a disorder characterized by papulovesicular eruptions on the trunk and proximal extremities. Acantholytic skin disorders without a primary immunological etiology are characterized by impaired intercellular adhesion between epidermal keratinocytes.
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Genetic acantholytic disorders include Darier disease and Hailey-Hailey disease; the pathogenesis of Grover disease is unknown.