Coagulase is an extracellular protein that converts fibrinogen (a soluble plasma protein) into fibrin (an insoluble protein), leading to the formation of a clot. The clot formation provides a means of differentiating S. aureus from other staphylococci that do not produce coagulase.

Understanding the Context

Coagulase is a protein enzyme produced by several microorganisms that enables the conversion of fibrinogen to fibrin. In the laboratory, it is used to distinguish between different types of Staphylococcus isolates. Coagulase is the enzyme which catalyses the conversion of fibrinogen to fibrin. It is most closely associated with pathogenicity, having previously been used in the microbiology laboratory to separate pathogens from non-pathogens.

110: Treatment of Coagulase-Negative Staphylococci Infection - Pharmacy

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110: Treatment of Coagulase-Negative Staphylococci Infection - Pharmacy
Staphylococci | Gram positive cocci | Microbiology | Achievable USMLE/1
SOLUTION: Cprmethicillin resistant coagulase negative staphylococci
SOLUTION: Cprmethicillin resistant coagulase negative staphylococci
SOLUTION: Efficacy of vaccination on staphylococcus aureus and
SOLUTION: Efficacy of vaccination on staphylococcus aureus and
Staphylococci
Pervasive horizontal gene transfer in coagulase-negative Staphylococcus
Genetic engineering of untransformable coagulase-negative
Pervasive horizontal gene transfer in coagulase-negative Staphylococcus
SOLUTION: Prevalence and antibiotic susceptibility of coagulase
Serological Characteristics of Coagulase Positive and Negative
Slime-Producing Coagulase-Negative Staphylococci Isolated from Human
Emergence of Vancomycin Resistance in Coagulase-Negative Staphylococci
Proteins and polypeptides from coagulase-negative staphylococci
Pathology Outlines - Staph coagulase negative
Molecular epidemiology of coagulase-negative Staphylococcus species
Molecular epidemiology of coagulase-negative Staphylococcus species
Changes of coagulase-negative Staphylococci infections in children
Trends of Antimicrobial Susceptibility in Clinically Significant
Table 1.1 from Biofilm formation and antimicrobial resistance of
Coagulase‐negative staphylococci as reservoirs of genes facilitating
First Report of Antibiotic Resistant Coagulase-Negative Staphylococcus
Characterization of Biofilm Producing Coagulase-Negative Staphylococci
Coagulase-Negative Staphylococci Clones Are Widely Distributed in the
Technological and Safety Characterization of Coagulase-Negative
Technological and Safety Characterization of Coagulase-Negative
In Vitro Bacterial Competition of Staphylococcus aureus, Streptococcus
In Vitro Bacterial Competition of Staphylococcus aureus, Streptococcus
Update on Coagulase-Negative Staphylococci—What the Clinician Should Know

Key Insights

Coagulase is an enzyme-like protein and causes plasma to clot by converting fibrinogen to fibrin. Staphylococcus aureus produces two forms of coagulase: bound and free. Bound coagulase (clumping factor) is bound to the bacterial cell wall and reacts directly with fibrinogen. Tube coagulase test detects free coagulase (staphylocoagulase) which reacts with coagulase-reacting factor (CRF). CRF is a plasma protein, often described as a thrombin-like molecule, that serves as an activator.

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Final Thoughts

The coagulase enzyme is a protein produced by particular bacterial species that interacts with blood plasma. This enzyme possesses the distinct capability to induce the clotting of blood plasma. While S. aureus is the most commonly isolated coagulase-positive organism, there are several other species of Staphylococcus which are positive for coagulase activity. Coagulase is an enzymatic protein that is a thermostable thrombin-like substance, which converts fibrinogen into fibrin resulting in clotting or clumping. In S.

aureus, two different forms of coagulase are found; free coagulase and bound coagulase.